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3,5-DICHLORO-4-METHOXYBENZOIC ACID CAS:37908-97-7
ZhonghanProduct Overview
3,5-dichloro-4-methoxybenzoic acid is an organic compound with a specific structure and properties. Its molecular formula is C8H6ClO3 and its molecular weight is about 221.04. From the perspective of chemical structure, the compound is based on benzoic acid. The 3rd and 5th positions of the benzene ring are connected to chlorine atoms (-Cl), the 4th position is connected to methoxy (-OCH3), and the carboxyl group (-COOH) is connected to the 1st position of the benzene ring. These structures give it unique chemical activity and physical properties. In appearance, 3,5-dichloro-4-methoxybenzoic acid is usually a white to off-white crystalline powder with a certain stability and regular crystal morphology.
ZhonghanStructural formula
Molecular formula |
C8H6Cl2O3 |
Molecular weight |
221.04 |
Boiling point |
328.9±37.0 °C (Predicted) |
Density |
1.474±0.06 g/cm3 (Predicted) |
Storage conditions |
Sealed in dry, Room Temperature |
Acidity coefficient (pKa) |
3.73±0.10 (Predicted) |
Form |
solid |
Color |
Off-white |
ZhonghanPhysical properties
1. Chemical stability: At room temperature and pressure and general storage conditions, 3,5-dichloro-4-methoxybenzoic acid has good chemical stability. However, because its molecules contain carboxyl and methoxy groups, they may react under strong acidic and alkaline conditions. The carboxyl group will undergo a neutralization reaction under alkaline conditions to generate the corresponding carboxylate; the methoxy group may be protonated or even replaced by other groups under strong acidic conditions. In addition, the chlorine atom on the benzene ring may also undergo a nucleophilic substitution reaction under the action of specific nucleophilic reagents.
2. Solubility: This product is slightly soluble in water. This is because although there are polar carboxylic acids in its molecules, the presence of benzene rings, chlorine atoms and methoxy groups makes the overall polarity of the molecule relatively weak, and the interaction with water molecules is limited. However, it is soluble in a variety of organic solvents, such as ethanol, acetone, dichloromethane, etc. This solubility feature enables it to be fully dispersed in a suitable solvent system and participate in the reaction in organic synthesis reactions, which provides convenience for subsequent synthesis operations.
3. Reactivity: The reactivity of 3,5-dichloro-4-methoxybenzoic acid mainly comes from its carboxylic acid, methoxy group and chlorine atoms on the benzene ring. The carboxyl group is acidic and can react with bases to form salts. It can also undergo esterification reactions with alcohols to form corresponding lipid compounds. The methoxy group has an electron-donating effect, which will affect the electron cloud density on the benzene ring, thereby affecting the substitution reaction activity on the benzene ring. The chlorine atom on the benzene ring has a large electronegativity, which makes its ortho and para carbon atoms have a certain electrophilicity and easily undergo nucleophilic substitution reactions with nucleophilic reagents.
ZhonghanApplication Areas
1. Pharmaceutical field: As an important pharmaceutical intermediate, 3,5-dichloro-4-methoxybenzoic acid has a wide range of applications in pharmaceutical research. Chlorine- and methoxy-containing benzoic acid compounds often have special biological activities. By structurally modifying and functionalizing the compounds, a variety of drug molecules with special therapeutic effects can be synthesized, such as drugs for the treatment of cardiovascular diseases, nervous system diseases, and tumors. Its unique structure and reactivity provide rich possibilities for the design and synthesis of drug molecules.
2. Pesticide field: In the pesticide industry, 3,5-dichloro-4-methoxybenzoic acid also plays an important role. Chlorine-containing pesticides are usually highly effective and broad-spectrum, and the introduction of methoxy groups may improve the solubility, permeability and other properties of pesticides. By utilizing the special structure and reactivity of this compound, pesticide varieties with good insecticidal, fungicidal and herbicidal activities can be prepared, providing effective protection for agricultural production and promoting the development of gareen agriculture.
3. Materials Science: With the continuous development of materials science, 3,5-dichloro-4-methoxybenzoic acid is also used in the preparation of some new organic functional materials. For example, it can be used as a structural unit in the synthesis of polymers to give the materials special properties, such as improving the thermal stability and chemical corrosion resistance of the materials. It is used in high-performance coatings, engineering plastics and other fields.