Methyl-6-chloro-5-nitronicotinate CAS:59237-53-5

Methyl 6-chloro-5-nitronicotinate is a key fine chemical in the field of organic synthesis and pharmaceutical research and development. Its CAS number is 134107-71-4, its molecular formula is C7H5ClN2O4, and its molecular weight is 216.58.

In appearance, it is a light yellow to yellow crystalline powder with stable properties, which is convenient for storage and transportation. It is slightly soluble in water, soluble in common organic solvents such as methanol and acetonitrile, and has good adaptability in different reaction systems.

As an important intermediate, it can construct complex molecular structures through a variety of reactions in organic synthesis. In the pharmaceutical field, it is often used to synthesize antibacterial and antiviral drugs, playing a key role in conquering diseases. With a high purity of ≥98% (HPLC), it can meet the strict requirements of scientific research experiments and industrial production, and promote innovation and development in related fields.

product details

ZhonghanProduct Overview

Methyl 6-chloro-5-nitronicotinate is a fine chemical with important value in the fields of organic synthesis and pharmaceutical research and development. Its unique molecular structure determines that it has special physical and chemical properties and wide application potential.

ZhonghanStructural formula

Molecular formula	C7H5ClN2O4
Molecular weight	216.58
Density	1.500±0.06 g/cm3 (Predicted)
Storage conditions	under inert gas (nitrogen or Argon) at 2-8°C
Acidity coefficient (pKa)	-4.81±0.10 (Predicted)
Melting point	76 °C
Boiling point	317.8±37.0 °C (Predicted)
Form	solid
Color	Off-white to gray

ZhonghanPhysical properties

1. Appearance: It is a light yellow to yellow crystalline powder with relatively stable color and state, which is convenient for preliminary quality judgment and identification during production, storage and transportation.

2. Melting point: [The specific melting point value needs to be accurately determined. Melting point is an important indicator to measure product purity and quality stability. It is of key significance in product synthesis, purification and quality inspection].

3. Solubility: It is slightly soluble in water and has certain solubility in common organic solvents such as methanol, ethanol, acetonitrile, N,N-dimethylformamide (DMF), etc. This solubility feature enables it to play a role in different chemical reaction systems, providing a variety of options for organic synthesis reactions.

4. Stability: Under normal conditions of room temperature, dryness and light avoidance, the chemical properties are relatively stable. However, when encountering special conditions such as strong oxidants, strong alkalis, and high temperatures, the molecular structure may change and trigger chemical reactions, so environmental factors need to be strictly controlled during storage and use.

ZhonghanApplication Areas

1. Pharmaceutical field: As an important pharmaceutical intermediate, it plays an indispensable role in the research and development and production of many drugs. Its unique molecular structure contains chlorine atoms, nitro groups and ester groups, which provide abundant reaction sites for the construction of drug molecules with specific biological activities. For example, in the development of antimalarial drugs, by modifying and transforming the structure of 6-chloro-5-nitronicotinic acid methyl ester and combining it with other groups with antimalarial activity, new antimalarial drugs can be synthesized, providing new solutions for global malaria prevention and control; in the research of anticancer drugs, it can also be used as a key structural unit to participate in the construction of drug molecules with targeted anticancer activity, contributing to the fight against cancer, a major disease.

2. Organic synthesis: In organic synthetic chemistry, 6-chloro-5-nitronicotinic acid methyl ester is an important raw material for the synthesis of various complex organic compounds. Its active reaction sites can participate in a variety of organic chemical reactions such as nucleophilic substitution reactions, esterification reactions, coupling reactions, etc., thereby providing key structural fragments for the synthesis of organic materials with special structures and functions, functional dyes, organic catalysts, etc. For example, when synthesizing organic dyes with specific optical properties, by coupling them with other compounds containing conjugated structures, new dyes with unique absorption and emission spectra can be prepared, which are used in the fields of fluorescence detection, biological imaging, etc.